ʻO ka bioprinting 3D kahi ʻenehana hana holomua e hiki ai ke hana i nā ʻano kikoʻī a me nā hale kūʻokoʻa i ke ʻano o nā ʻāpana i hoʻopaʻa ʻia, e hana ana i kēia hoʻonohonoho ʻana e hōʻike i ke ʻano multicellular kūlohelohe o nā hale moku koko. Ua hoʻokomo ʻia kahi ʻano o nā bio-inks hydrogel e hoʻolālā i kēia mau hale; akā naʻe, loaʻa nā bio-inks i hiki ke hoʻohālikelike i ka haku ʻana o nā kīʻaha koko maoli he mau palena. ʻAʻole hiki i nā bio-inks i kēia manawa ke paʻi kiʻekiʻe a ʻaʻole hiki ke waiho i nā cell ola kiʻekiʻe i loko o nā hale 3D paʻakikī, a laila e hōʻemi i ko lākou pono.

No ka lanakila ʻana i kēia mau hemahema, ua hoʻomohala ʻo Gaharwar lāua ʻo Jain i kahi bio-ink nano-engineered hou e paʻi i ka 3D, anatomically pololei nā kīʻaha koko multicellular. Hāʻawi kā lākou ala i ka hoʻonā ʻana i ka manawa maoli no nā macrostructures a me nā microstructures-level tissue, ʻaʻole hiki i kēia manawa me nā bio-inks.

ʻO kahi hiʻohiʻona kūʻokoʻa loa o kēia bio-ink nano-engineered ʻo ia ka nānā ʻana i ka nui o ka cell density, hōʻike ia i ka paʻi kiʻekiʻe a me ka hiki ke pale i nā cell encapsulated mai nā ikaika shear kiʻekiʻe i ka wā o ke kaʻina bioprinting. He mea pono ke hoʻomaopopo ʻia ʻo 3D bio ʻO nā cell i paʻi ʻia e mālama i kahi phenotype olakino a hiki ke ola no kahi mahina ma hope o ka hana ʻana.

Me ka hoʻohana ʻana i kēia mau hiʻohiʻona kūʻokoʻa, ua paʻi ʻia nā bio-inks nano-engineered i loko o nā kīʻaha koko cylindrical 3D, i haku ʻia me nā moʻomeheu ola o nā endothelial cell a me nā ʻiʻo vascular smooth muscle, e hāʻawi ana i nā mea noiʻi i ka manawa e hoʻohālikelike i nā hopena o nā kīʻaha koko a nā maʻi.

Hāʻawi kēia pahu bioprinted 3D i kahi mea hana no ka hoʻomaopopo ʻana i ka pathophysiology o nā maʻi vascular a me ka loiloi ʻana i nā lāʻau lapaʻau, nā meaʻawaʻawa a i ʻole nā ​​​​mea kemika ʻē aʻe i nā hoʻokolohua preclinical.