I loko o ke kino o ke kanaka, hilinaʻi nui ka ikehu i ka tricarboxylic acid cycle, e hoʻohana ana i ka D-glucose ma ke ʻano he mea ikehu. I ka wā lōʻihi, ua hoʻokumu ke kino o ke kanaka i kahi ʻōnaehana koʻikoʻi maʻemaʻe a kikoʻī e ʻike a hoʻololi i nā molekole glucose. Me ka hoʻomaikaʻi ʻana i ke kūlana ola o nā kānaka, ʻo ka maʻi diabetes, ka "pepehi haʻahaʻa", ua hoʻopilikia nui i ke olakino o ka poʻe a lawe mai i kahi ukana waiwai nui i ke kaiāulu. ʻO ke kiʻekiʻe o ka glucose koko pinepine a me ka hoʻokomo ʻana i ka insulin e hōʻeha i nā maʻi. Aia kekahi mau pilikia e like me ka paʻakikī i ka mālama ʻana i ka nui o ka injection a me ka laha ʻana o nā maʻi koko. No laila, ʻo ka hoʻomohala ʻana i nā biomaterials bionic no ka hoʻokuʻu ʻana i ka insulin i hoʻokuʻu ʻia i ka naʻauao he hopena maikaʻi loa ia e hoʻokō ai i ka mana lōʻihi o nā pae glucose koko i nā maʻi maʻi maʻi.

Nui nā ʻano isomers glucose i loko o nā meaʻai a me nā wai kino o ke kino kanaka. Hiki i nā enzyme biological o ke kino o ke kanaka ke hoʻomaopopo pololei i nā molekala glucose a loaʻa kahi kiʻekiʻe o ka kikoʻī. Eia nō naʻe, loaʻa i ka kemika synthetic ka ʻike kikoʻī o nā molekole glucose. Paʻakikī loa ka hale. ʻO kēia no ka mea he ʻano like loa ke ʻano o ka molecular molecular glucose a me kona mau isomers (e like me ka galactose, fructose, etc.), a he hui hydroxyl wale nō kā lākou, he paʻakikī ke ʻike pololei ʻia. ʻO ka liʻiliʻi liʻiliʻi liʻiliʻi i hōʻike ʻia he hiki ke hoʻomaopopo i ka glucose-specific e pili ana i nā pilikia āpau e like me ke kaʻina hana synthesis paʻakikī.

I kēia mau lā, ua hui pū ka hui o Professor Yongmei Chen a me Associate Professor Wang Renqi o Shaanxi University of Science and Technology me Associate Professor Mei Yingwu o Zhengzhou University e hoʻolālā i kahi ʻano hou e pili ana i ka bidentate-β- Hydrogel system of cyclodextrin. Ma ka hoʻokomo pololei ʻana i ʻelua mau pūʻulu substituent phenylboronic acid ma 2,6-dimethyl-β-cyclodextrin (DMβCD), ua hoʻokumu ʻia kahi molecular slit e like me ke ʻano topological o D-glucose, hiki ke hui pū ʻia me nā molekala D-Glucose. a hoʻokuʻu i nā protons, e hoʻohūhū ai ka hydrogel, a laila e hoʻokuʻu koke i ka insulin preloaded i loko o ka hydrogel e hoʻokuʻu koke ʻia i loko o ke koko. ʻO ka hoʻomākaukau ʻana i ka bidentate-β-cyclodextrin e koi wale i ʻekolu mau ʻanuʻu o ka pane ʻana, ʻaʻole koi i nā kūlana synthesis paʻakikī, a kiʻekiʻe ka hopena. ʻO ka hydrogel i hoʻopiha ʻia me ka bidentate-β-cyclodextrin e pane koke i ka hyperglycemia a hoʻokuʻu i ka insulin i nā ʻiole maʻi maʻi type I, hiki ke hoʻokō i ka mana lōʻihi o nā pae glucose koko i loko o 12 mau hola.