Abahanga bavumbuye uburyo bwo kugenzura ingirabuzimafatizo nyinshi mu ngirabuzimafatizo zikora imisemburo, zifungura umuryango w’umusaruro unoze kandi urambye w’ibicuruzwa bishingiye kuri bio.

Ubushakashatsi bwatangajwe mu bushakashatsi bwa Nucleic Acide bwakozwe n'abashakashatsi bo mu kigo cya DSM cya Rosalind Franklin Biotechnology Centre i Delft, mu Buholandi na kaminuza ya Bristol. Ubushakashatsi bwerekana uburyo bwo gufungura ubushobozi bwa CRISPR bwo kugenzura genes nyinshi icyarimwe.

Umusemburo wa Baker, cyangwa izina ryuzuye wahawe na Saccharomyces cerevisiae, bifatwa nkimbaraga nyamukuru mubinyabuzima. Mu myaka ibihumbi, ntabwo yakoreshejwe mu gutanga imigati n'inzoga gusa, ariko uyumunsi irashobora kandi gushushanywa kugirango ikore urukurikirane rwibindi bikoresho byingirakamaro bigize ishingiro ryimiti, lisansi, ninyongeramusaruro. Ariko, biragoye kugera kumusaruro mwiza wibicuruzwa. Birakenewe guhuza no kwagura urusobe rwibinyabuzima rwibinyabuzima muri selire mugutangiza imisemburo mishya no guhindura imiterere ya gene.