Abashakashatsi b'Abanyamerika bakoze ubushakashatsi ku binyabuzima byihishe inyuma yo gutwika amavuta, bagaragaza poroteyine igira uruhare runini mu kugenzura metabolisme, kandi bagaragaza ko guhagarika ibikorwa byayo bishobora guteza imbere iyi mbeba. Iyi poroteyine yitwa Them1 ikorwa mu binure byijimye byumuntu, bitanga icyerekezo gishya kubashakashatsi gushakisha uburyo bunoze bwo kuvura umubyibuho ukabije.
Abashakashatsi bari inyuma yubu bushakashatsi bushya bamaze imyaka igera ku icumi biga kuri Them1, kandi bashishikajwe nuburyo imbeba zitanga proteine nyinshi mu ngingo za adipose zijimye zijimye mu gihe cy'ubukonje. Bitandukanye na tipusi yera ya adipose ibika imbaraga zirenze mumubiri nka lipide, tissue adipose yumukara itwikwa vuba numubiri kugirango bitange ubushyuhe mugihe dukonje. Kubera iyo mpamvu, ubushakashatsi bwinshi bwo kurwanya umubyibuho ukabije bwibanze ku mbaraga zo guhindura ibinure byera ibinure byijimye.
Abashakashatsi bizeye gukora ubushakashatsi bushingiye kuri ubwo bushakashatsi bwimbeba hakiri kare aho imbeba zahinduwe genetike kugirango zibuze. Kubera ko bakekaga ko Them1 ifasha imbeba kubyara ubushyuhe, bari biteze ko kuyikuramo byagabanya ubushobozi bwabo bwo kubikora. Ariko biragaragara ko muburyo bunyuranye, imbeba zabuze iyi proteine zitwara imbaraga nyinshi kugirango zitange karori, kuburyo mubyukuri zikubye kabiri imbeba zisanzwe, ariko zikomeza gutakaza ibiro.
Ariko, mugihe usibye gene ya Them1, imbeba izatanga ubushyuhe bwinshi, ntabwo ari munsi.
Mu bushakashatsi buherutse gusohoka, abahanga bakoze ubushakashatsi ku mpamvu zitera iki kintu gitunguranye. Ibi bikubiyemo kwitegereza mubyukuri ingaruka za Them1 kuri selile zijimye zijimye zikura muri laboratoire ukoresheje microscopes yumucyo na electron. Ibi byerekana ko uko ibinure bitangiye kwaka, molekile ya Them1 ihinduka ryimiti, bigatuma ikwirakwira hose.
Imwe mu ngaruka ziterwa no gukwirakwizwa ni uko mitochondriya, izwi cyane nka dinamike selile, ishobora guhindura ububiko bwamavuta mu mbaraga. Amavuta yo gutwika amavuta amaze guhagarara, poroteyine ya Them1 izahita ihinduranya imiterere iri hagati ya mitochondriya n’ibinure, bizongera kugabanya ingufu zitanga ingufu.
Kwerekana amashusho menshi-yerekana: Them1 protein ikora mumyanya ya adipose yumukara, itunganijwe muburyo bubuza gutwika ingufu.
Ubu bushakashatsi busobanura uburyo bushya bugenga metabolism. Them1 yibasiye umuyoboro w'ingufu kandi igabanya itangwa rya lisansi kuri mitochondriya yaka ingufu. Abantu kandi bafite ibinure byijimye, bizatanga Them1 nyinshi mugihe cyubukonje, ubwo bushakashatsi rero bushobora kugira ingaruka zishimishije zo kuvura umubyibuho ukabije.
