Igabanijwemo cyane imiti ya POLYPEPTIDE YUBUVUZI, antibiyotike ya peptide, inkingo, peptide y’ubuhinzi yica udukoko, peptide yo kugaburira imiti, amavuta yo kwisiga ya buri munsi, peptide ya SOYBEAN yibiryo, peptide ya CORN, peptide yumusemburo, peptide yo mu nyanja.
Duhereye ku mikorere, irashobora kugabanywamo peptide irwanya umuvuduko ukabije, peptide ya antioxydeant, peptide igabanya cholesterol, peptide ikora opioid, peptide ikora cyane, F-agaciro ka oligopeptide, ibiryo bya peptide nibindi.
Peptide ikora, hamwe nimirire, imisemburo, kubuza enzyme, kugenzura ubudahangarwa, antibacterial, antiviral, antioxydeant bifitanye isano ya hafi. Peptide isanzwe igabanyijemo: imiti ya peptide nibicuruzwa byubuzima bwa peptide. Imiti gakondo ya peptide ni imisemburo ya peptide. Iterambere ryimiti ya peptide ryatejwe imbere mubice bitandukanye byo gukumira no kurwanya indwara, cyane cyane mubice bikurikira.
Kurwanya ibibyimba polypeptide
Tumorigenesi nigisubizo cyibintu byinshi, ariko amaherezo bikubiyemo kugenzura imvugo ya oncogene. Habonetse genes nyinshi zijyanye nibibyimba nibintu byabigenewe byabonetse mumwaka wa 2013. Kugenzura peptide ihuza cyane cyane niyi genes hamwe nibintu bigenga ibintu byahindutse ahantu hashya mu gushakisha imiti igabanya ubukana. Kurugero, somatostatine yakoreshejwe mu kuvura ibibyimba bya endocrine ya sisitemu y'ibiryo; Abashakashatsi b'Abanyamerika basanze hexapeptide ishobora kubuza cyane adenocarcinoma muri vivo; Abashakashatsi bo mu Busuwisi bavumbuye octapeptide itera apoptose mu ngirabuzimafatizo.
Antiviral polypeptide
Muguhuza reseptor zihariye kuri selile yakira, virusi adsorb selile kandi ikishingikiriza kuri protease yihariye yo gutunganya poroteyine no kwigana aside nucleic. Kubwibyo, peptide ihuza kwakira reseptor selile cyangwa imbuga zikora nka protease za virusi zirashobora kwerekanwa mubitabo bya peptide kugirango bivurwe na virusi. Muri 2013, Kanada, Ubutaliyani ndetse n’ibindi bihugu basuzumye peptide ntoya nyinshi zirwanya indwara ziva mu isomero rya peptide, kandi zimwe muri zo zinjiye mu cyiciro cy’ibizamini by’amavuriro. Muri Kamena 2004, Ikigo cya Microbiology, Ishuri Rikuru ry’Ubumenyi ry’Ubushinwa ryatangaje ko icyerekezo cyingenzi cy’umushinga wo guhanga ubumenyi wakozwe n'Ikigo cya Microbiology, Ishuri Rikuru ry'Ubushinwa, "Ubushakashatsi ku mikorere ya SARS-CoV fusion selile na Fusion inhibitor", kikaba cyarakozwe n'Ikigo cya Microbiology, Ishuri Rikuru ry'Ubushinwa n'Ikigo cya Virusi ya Kijyambere, Ubumenyi bw'ubuzima, kaminuza ya Wuhan, cyari cyateye intambwe igaragara. Ubushakashatsi bwerekanye ko peptide ya HR2 yateguwe ishobora guhagarika neza kwanduza ingirabuzimafatizo zifite virusi ya SARS, kandi uburyo bwiza bwo kubuza ni ubwinshi bwa nmoles. Iterambere ryingenzi ryanakozwe mu bushakashatsi bwo kubuza kwandura virusi ya synthesize kandi bugaragaza peptide ya HR1 hamwe na vitro yo guhuza vitro ya HR1 na HR2. Imiti ya peptide yakozwe kugirango ikingire virusi ya SARS irashobora kwirinda kwandura virusi, naho ku barwayi banduye, ikarinda kwandura virusi mu mubiri. Umuti wa polypeptide ufite ibikorwa byo gukumira no kuvura. Abashakashatsi bo mu kigo cy’ubushakashatsi bw’ubushakashatsi bw’akagari ka kaminuza ya kane y’ubuvuzi ya Gisirikare bahujije peptide icyenda zishobora gukumira no gukumira virusi ya SARS yinjira mu ngirabuzimafatizo.
Cytokines yigana peptide
Gukoresha reseptor ya cytokine izwi kugirango yerekane cytokine yigana mumasomero ya peptide yabaye ahantu h’ubushakashatsi mu mwaka wa 2011. Kugenzurwa n’abantu bo mu mahanga erythropoietin, abantu bongera imisemburo ya platine, imisemburo ikura, imikurire y’imitsi kandi ko ibintu bitandukanye bikura nka interleukin - Peptide 1 yigana, kwigana peptide ya amine acide ikurikirana hamwe ningirabuzimafatizo ihuye iratandukanye, urukurikirane rwa acide amine ariko rufite ibikorwa bya cytokine, kandi ifite ibyiza bya bitouburemere bwa molekile. Muri 2013 iyi cytokine yigana peptide iri gukorwa iperereza ryibanze cyangwa ryubuvuzi.
Antibacterial ikora peptide
Iyo udukoko twatewe imbaraga n’ibidukikije, hakorwa umubare munini wa peptide cationic peptide hamwe nibikorwa bya antibacterial. Muri 2013, hasuzumwe ubwoko burenga 100 bwa peptide ya mikorobe. Muri vitro no muri vivo ubushakashatsi bwemeje ko peptide nyinshi zirwanya mikorobe zidafite imbaraga za antibacterial na bactericidal gusa, ahubwo zishobora no kwica selile.
Urukingo rwa peptide
Urukingo rwa Peptide hamwe n’inkingo za aside nucleique ni kimwe mu bintu by’ingenzi mu bijyanye n’ubushakashatsi bw’inkingo mu 2013. Ubushakashatsi bwinshi n’iterambere ry’inkingo za peptide virusi byakorewe ku isi mu 2013. Urugero, mu 1999, NIH yasohoye ibisubizo byubuvuzi byubwoko bubiri bwinkingo ya virusi ya virusi ya VIH-I ku bantu; Polipeptide yapimwe muri poroteyine yo hanze ya E2 ya virusi ya hepatite C (HCV), ishobora gukangurira umubiri gukora antibodiyide zirinda. Amerika irimo gutegura urukingo rwa malariya polyvalent antigen polypeptide; Urukingo rwa papillomavirus peptide yumuntu kuri kanseri yinkondo y'umura rwinjiye mu cyiciro cya kabiri cy’amavuriro. Ubushinwa nabwo bwakoze imirimo myinshi mu bushakashatsi bw’inkingo zitandukanye za polypeptide.
Peptide yo gusuzuma
Ikoreshwa nyamukuru rya peptide mugusuzuma ni nka antigene, antibodies kugirango tumenye ibinyabuzima bitera indwara. Antigene ya polypeptide irasobanutse kuruta mikorobe kavukire cyangwa parasitike ya poroteyine kandi byoroshye kuyitegura. Antibody detection reagents yateranijwe hamwe na antigene ya polypeptide muri 2013 harimo: A, B, C, G virusi y’umwijima, virusi itera sida, virusi ya cytomegalovirus, virusi ya herpes simplex, virusi ya rubella, Treponema pallidum, cysticercose, trypanosoma, indwara ya Lyme na reagato de rheumatoide. Hafi ya antigene ya peptide yakoreshejwe yabonetse muri proteine kavukire yumubiri utera indwara, kandi zimwe zari peptide nshya zabonetse mubitabo bya peptide.
