Nhanganyaya yeMGF:
Mechano Growth Factor Mechano Growth Factor, inowanzozivikanwa seMGF, inosiyana-siyana yeIGF-1, chinhu chekukura / kugadzirisa chinobva mukurovedza muviri kana kukuvara kwemhasuru tishu, Zvinoita kuti zviome kuziva mamwe maIGF akasiyana.
Chii chinoita kuti MGF ive yakakosha ibasa rayo rakasiyana mukukura kwemhasuru. MGF ine yakasarudzika kugona kukurudzira kutambisa matishu kukura uye kuvandudzwa ne activate tsandanyama stem masero uye kuwedzera upregulation yeprotein synthesis. Iyi yakasarudzika kugona inokurumidza kunatsiridza kupora uye inomhanyisa kukura kwemhasuru. Mukuwedzera kune IGF-1 receptor domain, MGF inotangawo muscle satellite (stem cell) cell activation, nokudaro kuwedzera protein synthesis turnover; Naizvozvo, kana ikashandiswa nemazvo, inogona kuvandudza zvakanyanya tsandanyama.
IGF-1 inonzi 70-amino acid hormone ine chimiro chakafanana ne insulini inobudiswa nechiropa, uye IGF-1 secretion inokonzerwa nekudzivirira uye kusunungurwa kwekukura kwehomoni (GH) mumuviri. IGF-1 inobata anenge ese sero mumuviri, kunyanya nekuti inobatanidzwa mukugadzirisa masero. Kana nyama yemhasuru ikakuvadzwa, izvi zvinogadzira kuita mumuviri kunonzi T
IGF-1 yakakamurwa kuita maviri akasiyana, IGF-1Ec uye IGF-1Ea, yaimbova MGF.
MGF splicing akasiyana eGF maviri anogadzirwa nechiropa:
Yekutanga ndeye IGF-1EC: iyi ndiyo nhanho yekutanga kuburitsa iyo igf splicing musiyano, uye ichaita.
Inomutsa satellite cell activation
Yechipiri ndeye hepatic IGF-IEA: Ichi chikamu chechipiri chekusunungurwa kwegf kubva pachiropa, uye anabolic mabhenefiti ayo maduku zvikuru kupfuura ekutanga.
MGF inosiyana kubva kune yechipiri musiyano, IGF-IEa, pakuti ine peptide yakasiyana sequence uye ine basa rekuzadza masero e satellite mumaskeletal muscle; Mune mamwe mazwi, inopa akawanda anabolic mabhenefiti uye akareba mhedzisiro pane iyo yechipiri MGF chiropa musiyano.
Saka iwe unongo funga nezve MGF seyakanyanya kukwidziridzwa musiyano we igf maererano nevanabolic mabhenefiti. Mushure mekudzidziswa, IGF-I gene inoparadzanisa MGF uye zvino inokonzera hypertrophy uye kugadziriswa kwekukuvara kwemhasuru yemunharaunda nekuita masero akaoma uye mamwe maitiro anokosha evanabolic (kusanganisira protein synthesis inotsanangurwa pamusoro apa) uye kuwedzera nitrogen kuchengetedza mumusuru.
Mune makonzo, zvimwe zvidzidzo zvakaratidza kuwedzera kwe20% mumhasuru nejekiseni rimwe chete reMGF, asi ndinofunga kuti dzakawanda zvezvidzidzo izvi hazvina kururama, asi kukwanisa kweMGF hakugoneki.
Iyo splicing yeMGF inomutsa satellite maseru, zvichitungamira mukukura kwemhasuru fibers mumuviri. Mukuwedzera, kuvapo kweMGF kunowedzera chiyero cheprotein synthesis yemuviri, nokudaro kukurudzira myohypertrophy uye kuwedzera! Kukura! Kukura! Ehe zvakatonyanya kukosha kugadzirisa 196 iripo
Ehe, zvinhu zvekudzoreredza zvine chekuita neMGF hapana mubvunzo kuti inzvimbo inoyevedza yeMGF.
Nepo kushanda kweMGF kungaite sekunge kuvhiringika pakutanga, maitiro acho anova nyore kana ukaatarisa nhanho nhanho:
1.IGF-1 inosunungurwa nekurovedza muviri (inoitika mushure mekurovedza muviri)
2. Slice IGF-1 uye MGF
3.MGF inomutsa kudzoreredzwa kwemhasuru tishu mushure mekudzidziswa kukuvadzwa nekuita mhasuru stem masero
Kushandiswa kweMGF
Chii chinoitika kumhasuru dzako paunodzidzisa? Iwo anoputsika, maseru anokuvadzwa, mhasuru tishu dzinoda kugadziriswa, uye muviri wako unoburitsa maviri mafomu eMGF splicing akasiyana. Yekutanga kuburitswa kwechiropa 1 musiyano pamusoro inofambisa tsandanyama kupora. Ko kana MGF isipo? Zviri nyore, masero emhasuru haagadzirise uye anofa. Tsandanyama masero masero akakura asingakwanisi kupatsanura, masero emhasuru anotorwa kubva mumasero etsandanyama anopatsanurwa kuita tsandanyama masero kuburikidza ne mitosis, saka muviri haugone kugadzirisa matishu kuburikidza nekutsiviwa kwesero mushure mekukuvara kwemhasuru, unogona chete kugadzirisa masero ekutanga, kana masero haagadziriswi, anofa. Nyama dzako dzinoita dikiuye zvishoma. Nekushandisa MGF, kupora kwemuviri kunogona kukwidziridzwa uye mhasuru tishu masero anogona kuwedzerwa nekukurudzira kuzara kwakazara kwemaseru setiraiti. Panyaya yedosi, 200mcg bilateral spot injection ndiyo yakanakisa sarudzo (spot jekiseni rinodiwa kune MGF). Dambudziko chete neMGF nderekuti hafu yehupenyu hwayo ipfupi kwazvo, 5-7 maminetsi chete, uye inoda kushandiswa nekukurumidza mushure mekudzidziswa kuti iwane mhedzisiro, nepo vanhu vazhinji vasina nguva yekuishandisa panguva yehwindo iri. mushure mekudzidziswa.
Chii chinonzi PEG-MGF?
Sezvambotaurwa pamusoro apa, dhizaini huru yeMGF inguva yayo pfupi yekuita, saka shanduro yenguva refu yeMGF, PEG MGF, yakagadzirwa. Nekuwedzera PEG(polyethylene glycol, isiri-chepfu yekuwedzera) kuMGF, hafu yehupenyu hweMGF inogona kuwedzerwa kubva pamaminetsi kusvika maawa. Nguva yakawedzerwa yebasa inoreva kuti kushandiswa kwayo uye kushandiswa kwakasiyana-siyana kuchavandudzwa zvikuru, uye PEG MGF ine maitiro ekugadzirisa apo musuru unokuvadzwa kana kurwara, pane kungogumira pane imwe pfungwa.
Ndinoshandisa sei PEG-MGF
Nzvimbo inotevera yatinofanira kutarisa pairi ndeyekuti tingawana sei zvakanyanya kubva muMGF's refu-acting version. Kana tsandanyama dzako dzakuvadzwa, muviri wako unoburitsa pulses yeMGF clip-on variant inotsanangurwa pamusoro apa, inoteverwa nefomu refu-inoshanda kubva pachiropa ine yakaderera anabolic mabhenefiti. Saka zvinoita sekunge marara kubaya MGF panguva ino, nekuti uri kungoderedza kusunungurwa kwemuviri wega, kwete kuiwedzera. Naizvozvo, kushandisa PEG MGF pamazuva asiri ekurovedza muviri ndiyo nzira yakanakisa. Nekuda kwekukuvara kwemhasuru, MGF ine akawanda mareceptor, uye mhedzisiro yayo ndeye systemic. Nekuwedzera nitrogen kuchengetedza, mapuroteni ekuchinja uye satellite cell activation, zvichabatsira kudzoreredza tsandanyama dzese. Nekuita izvi, uri kuwedzera hurefu hwenguva inotora muviri wega kugadzirisa tsandanyama uye nzira dzekukura. Kushandisa PEG MGF pamwe chete neIGF yakakwana, asi nekuda kwesimba rakasimba rekugamuchira IGF, kana ukashandisa zvose IGF-1 uye PEG MGF, kushanda kweMGF kuchaderedzwa.
Mazano angu ndeaya anotevera:
IGF DES kana IGF1-LR3 inoshandiswa pamazuva ekudzidzira isati yadzidziswa, iyo isingakanganisi MGF kusunungurwa kubva pachiropa chemuviri. IGF-DES yakashandiswa kukurumidza kuvandudza nzvimbo yakarembera, uye ipapo MGF ye200-400 MCG yakashandiswa zuva raitevera kuti iwedzere kudzoreredza uye kukura michina. Perfect synergy.
PEG MGF kuchengetedza
Iyo MGF inogona kuchengetwa mufiriji kusvika kumwedzi mitanhatu. Dzivisa kutarisana nekupisa kana zuva
Pasi pechiedza.
