Jirka bini'aadamka, dheef-shiid kiimikaadka tamarta wuxuu inta badan ku tiirsan yahay wareegga tricarboxylic acid, kaas oo u isticmaala D-glucose sida walax tamar ah. Horumarka muddada fog, jidhka bini'aadamku waxa uu samaystay nidaam bayooloji oo casri ah oo gaar ah kaas oo aqoonsada oo metabolizes molecules gulukoosta. Marka la hagaajiyo heerka nolosha dadka, cudurka macaanka, " dilaaga aamusan ", ayaa si xun u halis galiyay caafimaadka dadka waxayna u keentay culeys dhaqaale oo culus bulshada. Heerarka gulukooska dhiigga ee soo noqnoqda iyo cirbadaha insulinta waxay bukaannada u keenaan raaxo darro. Waxa kale oo jira khataro ay ka mid yihiin in ay ku adkaato xakamaynta qiyaasta duridda iyo faafidda cudurrada dhiigga. Sidaa darteed, horumarinta biomaterials bionic si loo sii daayo insuliinta la xakameeyey caqli-gal ayaa ah xalka ugu habboon ee lagu gaaro kontoroolka muddada-dheer ee heerarka gulukooska dhiigga ee bukaanka sonkorowga qaba.

Waxaa jira noocyo badan oo isomers gulukoos ah labadaba cuntada iyo dareeraha jidhka ee jidhka bini'aadamka. Enzymes noolaha ee jidhka bini'aadamka ayaa si sax ah u aqoonsan kara molecules gulukooska waxayna leeyihiin heerar sare oo gaar ah. Si kastaba ha ahaatee, kiimiko synthetic waxay leedahay aqoonsi gaar ah oo ah unugyada gulukooska. Qaab dhismeedka waa mid aad u adag. Tani waa sababta oo ah qaab-dhismeedka molecular ee molecules gulukooska iyo isomers (sida galactose, fructose, iwm.) aad bay isugu dhow yihiin, waxayna leeyihiin hal koox oo shaqaynaysa oo hydroxyl ah, taas oo ay adagtahay in si sax ah loo ogaado kiimikaad ahaan. Xadhigyada kiimikaad ee dhowrka ah ee lagu soo warramey inay leeyihiin awood aqoonsi gaar ah oo gulukoos gaar ah ku dhawaad ​​dhamaantood waxay leeyihiin dhibaatooyin sida habka isku dhafka ah ee adag.

Dhawaan, kooxda Professor Yongmei Chen iyo Associate Professor Wang Renqi oo ka tirsan Jaamacadda Shaanxi ee Sayniska iyo Teknolojiyadda ayaa iskaashi la sameeyay Associate Professor Mei Yingwu ee Jaamacadda Zhengzhou si ay u naqshadeeyaan nooc cusub oo ku saleysan nidaamka bidentate-β- Hydrogel ee cyclodextrin. Iyadoo si sax ah loo soo bandhigayo koox ka mid ah kooxaha beddelka ah ee phenylboronic acid ee 2,6-dimethyl-β-cyclodextrin (DMβCD), jeex molecular oo waafaqsan qaab dhismeedka sare ee D-glucose ayaa la sameeyay, kaas oo si gaar ah loogu dari karo molecules D-glucose waxayna sii daayaan protons, taasoo keenta in hydrogel-ku bararo, taaso soo dedejisa in insulintii hore loogu shubay hydrogel si degdeg ah loogu sii daayo deegaanka dhiigga. Diyaarinta bidentate-β-cyclodextrin kaliya waxay u baahan tahay saddex tallaabo oo falcelin ah, uma baahna xaalado qallafsan oo adag, iyo wax-soo-saarka falcelinta ayaa sarreeya. Hydrogel-ka ku raran bidentate-β-cyclodextrin wuxuu si dhakhso ah uga jawaabaa hyperglycemia wuxuuna sii daayaa insulin nooca I jiirka macaanka, kaas oo ku guuleysan kara kontoroolka muddada dheer ee heerarka gulukooska dhiigga 12 saacadood gudahood.