Emzimbeni womntu, amandla e-metabolism ikakhulu axhomekeke kumjikelo we-tricarboxylic acid, esebenzisa i-D-glucose njengento yamandla. Kwixesha elide lokuziphendukela kwemvelo, umzimba womntu wenze inkqubo yebhayoloji entsonkothileyo kunye necacileyo eqaphela kwaye idibanise iamolekyu zeglucose. Ngokuphuculwa kwemigangatho yokuphila kwabantu, isifo seswekile, "umbulali othuleyo", uye wabeka engozini impilo yabantu kwaye wazisa umthwalo onzima wezoqoqosho kuluntu. Amanqanaba eglucose rhoqo egazini kunye neenaliti ze-insulin zizisa ukungonwabi kwizigulana. Kukwakho nemingcipheko enokubakho enjengobunzima bokulawula ithamo lokutofa kunye nokusasazeka kwezifo zegazi. Ke ngoko, ukuphuhliswa kwe-bionic biomaterials yokukhululwa kwe-insulin elawulwayo elawulwa bubulumko sisisombululo esifanelekileyo sokufezekisa ulawulo lwexesha elide lwamanqanaba eglucose yegazi kwizigulana ezinesifo seswekile.
Kukho iintlobo ezininzi ze-glucose isomers kukutya kunye nolwelo lomzimba lomzimba womntu. I-enzymes yebhayoloji yomzimba womntu inokuqaphela ngokuchanekileyo iimolekyuli ze-glucose kwaye ibe nenqanaba eliphezulu lezinto ezithile. Nangona kunjalo, i-synthetic chemistry inokuqatshelwa okuthe ngqo kweemolekyuli zeglucose. Isakhiwo sinzima kakhulu. Oku kungenxa yokuba isakhiwo se-molecular of glucose molecules kunye ne-isomers zayo (ezifana negalactose, i-fructose, njl.) zifana kakhulu, kwaye zineqela elilodwa kuphela elisebenzayo le-hydroxyl, okunzima ukuchongwa ngokuchanekileyo ngamachiza. Ii-ligands ezimbalwa zeekhemikhali eziye zaxelwa ukuba zine-glucose-specific recognition ability phantse zonke zineengxaki ezifana ne-complicated synthesis process.
Kungekudala, iqela likaNjingalwazi uYongmei Chen kunye noNjingalwazi oNxibeleleyo uWang Renqi weYunivesithi yaseShaanxi yeSayensi kunye neTekhnoloji ibambisene noNjingalwazi onguMei Yingwu weYunivesithi yaseZhengzhou ukuyila uhlobo olutsha olusekelwe kwi-bidentate-β-Hydrogel inkqubo ye-cyclodextrin. Ngokuzisa ngokuchanekileyo iqela le-phenylboronic acid substituent groups kwi-2,6-dimethyl-β-cyclodextrin (DMβCD), i-molecular slit ehambelana nesakhiwo se-topological ye-D-glucose yenziwe, enokuthi idibaniswe ngokukodwa kunye ne-D-Glucose i-molecules ibopha. kunye nokukhupha iiprotons, ezibangela ukuba i-hydrogel idumbe, ngaloo ndlela ikhuthaza i-insulin elayishwe kwangaphambili kwi-hydrogel ukuba ikhutshwe ngokukhawuleza kwindawo yegazi. Ukulungiswa kwe-bidentate-β-cyclodextrin kufuna kuphela amanyathelo amathathu okuphendula, ayifuni iimeko ezinzima ze-synthesis, kwaye isivuno sokuphendula siphezulu. I-hydrogel elayishwe nge-bidentate-β-cyclodextrin iphendula ngokukhawuleza kwi-hyperglycemia kwaye ikhuphe i-insulin kwiigundane zesifo sikashukela sohlobo lwe-I, ezinokufikelela kwixesha elide lokulawula amanqanaba e-glucose yegazi kwiiyure ze-12.
