I-Anastrozole, i-estrogen buster

 KNOWLEDGE    |      2023-03-28

Ama-Estrogen busters


I-Anastrozole iyisidakamizwa esinamandla sokulwa nabesifazane esiyingxenye ye-aromatase inhibitor, okuyisidakamizwa esilwa nabesifazane esidumile phakathi kwabakhi bomzimba.


I-Anastrozole isetshenziswa ngabasebenzisi abaningi be-steroid ngesikhathi sokujikeleza ukucindezela ukusabela kokungena. I-steroids eminingi i-aromatize futhi ibangele imiphumela emibi ye-estrogen, okuyinto i-anastrozole isisombululo esihle kuyo. Empeleni kunciphisa amazinga e-testosterone emzimbeni ngamaphesenti angu-80. Lokhu kuyinzuzo ebalulekile kubasebenzisi be-steroid, kanye nokugqugquzela ukukhiqizwa kwe-hormone ye-luteinizing kanye ne-follicle stimulating hormone.


Kubasebenzisi be-steroid, i-anastrozole ivimbela imiphumela emibi yokusabela kwe-inofemale yomuthi. Ngoba ama-steroids amaningi anephunga elimnandi emzimbeni futhi aguqulwa abe yi-estrogen, engabangela imiphumela emibi. Kuma-steroid, amazinga e-estrogen kubasebenzisi akhuphuka afike kusilinganiso esiphindwe kasikhombisa ngaphezu kwalabo abangasebenzisi, okubangela ukugcinwa kwamanzi okunamandla kanye ne-breast tip ectosis uma kuyekwa kungahloliwe. Ama-Aromatase inhibitors afana ne-anastrozole yiwona asebenza kahle kakhulu ekulawuleni i-oecytosis, kuyilapho ama-modulator amahomoni ocansi akhethiwe njenge-tamoxifen engasebenzi kahle kakhulu kunemithamo engu-0.5-MG evamile kubasebenzisi be-steroid. Bambalwa kakhulu abantu abazodinga igigabhayithi engaphezu kweyodwa, futhi ezimweni eziningi yanele ngokuphelele. Kodwa abasubathi bangaphambi komncintiswano bangase bakuthole kuwusizo ukuthatha u-0.5MG we-anastrozole ngosuku izinsuku ezingu-10 kuya kweziyi-14 ukuze uqinise imisipha.


Kubuye kunconywe ukwengeza i-anastrozole ekubuyiseleni kwe-PCT, okungagcina isilinganiso se-estrogen kuya ku-testosterone ngaphakathi kwebanga elivamile. Ngaphezu kwalokho, i-anastrozole inyusa amazinga e-hormone ye-luteinizing ne-follicle-stimulating hormone, futhi i-testosterone ye-endogenous ecindezelwe ingalulama ngokushesha okukhulu.