I-Tesamorelin peptide (INN) (igama lokuhweba elithi Egrifta) iwuhlobo lokwenziwa lwe-hormone yokukhula-i-hormone-releasing (GHRH) esetshenziswa ekwelapheni i-lipodystrophy ehlobene ne-HIV, evunywe ekuqaleni ku-2010. Ikhiqizwa futhi yathuthukiswa yi-Theratechnologies, Inc. eCanada. Umuthi uyi-peptide yokwenziwa ehlanganisa wonke ama-amino acid angama-44 we-GHRH yomuntu kanye nokwengezwa kweqembu le-trans-3-hexenoic acid.

I-Tesamorelin peptide iyi-analogue ye-peptide yokwenziwa ezinzile ye-hypothalamic peptide, i-Growth Hormone Releasing Hormone (GHRH) ekhonjiswe ekunciphiseni amafutha amaningi esiswini ezigulini ezine-HIV ezine-lipodystrophy. I-Lipodystrophy yisimo se-metabolic esibonakala ngokumelana ne-insulin, ukwabiwa kabusha kwamafutha, kanye ne-hyperlipidemia ehambisana nokwelashwa ngezidambisigciwane zokutheleleka nge-HIV.

I-Tesamorelin peptide iyi-analog ye-hormone-releasing hormone (GHRH) ekhonjiswe ukwandisa i-hormone yokukhula kanye namazinga e-IGF-1. I-Tesamorelin okwamanje i-GH ekhulula kakhulu i-hormone emakethe. Kuyi-peptide yomjovo ekhiqiza ukukhiqizwa kwemvelo okukhulu kwe-HGH (I-Human Growth Hormone). Ibophezela futhi ikhuthaze ama-receptors e-GHRH anamandla afanayo ne-GHHRH yethu yemvelo. Akuzange kuboniswe ukuthi kuthinte kakhulu amanye amahomoni e-pituitary emzimbeni.

I-Gland Stimulated: I-Pituitary Gland

IZINZUZO ZE-TESAMORELIN:

Yandisa ukukhiqizwa kwemvelo kwe-HGH (i-hormone yokukhula komuntu)

Yandisa i-IGF-1 (I-Insulin Growth Factor - 1) ngaphandle kokushintsha imingcele ye-glucose

Ama-triglycerides ancishisiwe

I-Visceral Adipose Tissue Encishisiwe (VAT)

Usayizi Wemidiya Oyehlisiwe we-Carotid Intima (cIMT)

Ukuqonda okuthuthukisiwe kubantu abadala abangaphezu kweminyaka engama-60.

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