Tesamorelin peptide (INN) (lub npe lag luam Egrifta) yog ib daim ntawv hluavtaws ntawm kev loj hlob-hormone-tso cov tshuaj hormone (GHRH) uas yog siv los kho cov kab mob HIV-associated lipodystrophy, tau pom zoo pib xyoo 2010. Nws yog tsim thiab tsim los ntawm Theratechnologies, Inc. . ntawm Canada. Cov tshuaj yog ib qho hluavtaws peptide uas muaj tag nrho 44 amino acids ntawm tib neeg GHRH nrog ntxiv ntawm ib pawg trans-3-hexenoic acid.

Tesamorelin peptide yog ib qho stabilized hluavtaws peptide analogue ntawm hypothalamic peptide, Kev Loj Hlob Hormone Releasing Hormone (GHRH) qhia rau kev txo qis hauv plab rog hauv cov neeg mob HIV nrog lipodystrophy. Lipodystrophy yog ib qho mob metabolic uas tshwm sim los ntawm kev tiv thaiv insulin, kev faib tawm rog rog, thiab hyperlipidemia cuam tshuam nrog kev kho tshuaj tiv thaiv kab mob HIV.

Tesamorelin peptide yog ib qho kev loj hlob hormone-tso cov tshuaj hormones (GHRH) analog uas tau pom tias yuav ua rau muaj kev loj hlob hormone thiab IGF-1 qib. Tesamorelin tam sim no yog qhov zoo tshaj plaws GH tso cov tshuaj hormones ntawm kev ua lag luam. Nws yog ib qho tshuaj peptide uas tsim kom muaj ntau dua ntuj tsim ntawm HGH (Human Growth Hormone). Nws khi thiab txhawb nqa tib neeg GHRH receptors nrog lub zog zoo li peb tus kheej GHRH. Nws tsis tau pom tias muaj feem cuam tshuam rau lwm cov tshuaj hormones pituitary hauv lub cev.

Gland Stimulated: Pituitary Gland

Cov txiaj ntsig ntawm TESAMORELIN:

Ua kom lub ntuj tsim tawm ntawm HGH (tib neeg kev loj hlob hormone)

Nce IGF-1 (Insulin Growth Factor - 1) yam tsis hloov pauv cov piam thaj.

Txo triglycerides

Txo Visceral Adipose Tissue (VAT)

Txo Carotid Intima Media Loj (cIMT)

Txhim kho kev paub hauv cov neeg laus dua 60 xyoo.

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