Anastrozole, onye na-emepụta estrogen

 KNOWLEDGE    |      2023-03-28

Estrogen busters


Anastrozole bụ ọgwụ mgbochi siri ike nke nwanyị bụ nke aromatase inhibitor, nke bụ ọgwụ na-ewu ewu nke nwanyị na-ewu ewu n'etiti ndị na-ewu ahụ.


Anastrozole na-eji ọtụtụ ndị ọrụ steroid eme ihe n'oge mgbasa ozi iji gbochie mmeghachi omume inectation. Ọtụtụ steroid aromatize na-akpata estrogen mmetụta, nke anastrozole bụ ezigbo ngwọta. Ọ na-ebelata ọkwa testosterone n'ime ahụ site na pasent 80. Nke a bụ uru bara uru maka ndị ọrụ steroid, yana na-akpali mmepụta nke luteinizing hormone na follicle stimulating hormone.


Maka ndị na-arụ ọrụ steroid, anastrozole na-egbochi mmetụta nke mmeghachi omume inofemale nke ọgwụ. N'ihi na ọtụtụ steroid bụ aromatized n'ime ahụ ma ghọọ estrogen, nke nwere ike ịkpata mmetụta. Na steroid, ọkwa estrogen n'ime ndị ọrụ na-arị elu na nkezi nke ugboro asaa karịa nke ndị na-abụghị ndị ọrụ, na-akpata nnukwu nchekwa mmiri na ọnụ ara ectosis ma ọ bụrụ na ejideghị ya. Aromatase inhibitors dị ka anastrozole bụ ndị kasị dị irè na ịchịkwa oecytosis, ebe ndị na-ahọrọ mmekọahụ homonụ modulators dị ka tamoxifen bụ nnọọ obere irè karịa doses nke 0.5-MG bụ ndị nkịtị maka steroid ọrụ. Ọ bụ mmadụ ole na ole ga-achọ ihe karịrị otu gigabyte, na n'ọtụtụ ọnọdụ ọ zuru oke. Mana ndị na-eme egwuregwu tupu asọmpi nwere ike ịhụ na ọ na-enye aka ị were 0.5MG nke anastrozole kwa ụbọchị maka ụbọchị 10 ruo 14 iji mee ka akwara sie ike.


A na-atụ aro ka ịgbakwunye anastrozole na PCT mgbake, nke nwere ike ịnọgide na-enwe oke nke estrogen na testosterone n'ime oke nkịtị. Na mgbakwunye, anastrozole na-abawanye ọkwa nke homonụ luteinizing na homonụ na-akpali follicle, na testosterone endogenous nke emechiri emechi nwere ike ịgbake na ọkwa nkịtị ngwa ngwa.