Hobane ho latela khopolo ea protheine, sele e ’ngoe le e ’ngoe ’meleng le likarolo tsohle tsa bohlokoa li na le liprotheine tse amehang. Protheine e nka 16% ~ 20% ea boima ba 'mele oa motho. Ho na le mefuta e mengata ea protheine 'meleng oa motho, e nang le thepa le mesebetsi e fapaneng, empa kaofela ha eona e entsoe ka mefuta e 20 ea amino acid ka litekanyo tse fapaneng,' me e lula e sebelisoa le ho nchafatsoa 'meleng.
Li-amino acid tsena tse 20 'meleng oa motho li ka kopanngoa ka bolokolohi li-peptide tse 2,020, e leng palo e kholo haholo. Ho ea ka pono ea mantlha ea hore sebopeho sa baeloji se etsa qeto ea ts'ebetso, molao-motheo oa ts'ebetso ea peptide e 'ngoe le e' ngoe e sebetsang o rarahane haholo. Joalo ka peptide ea antibacterial e khahlanong le ho ruruha, peptide ea taolo ea 'mele ho thymosin.
Antibacterial anti-inflammatory peptide: antibacterial-anti-inflammatory peptide (C-L)→ qoso e ntle → ketso ea baktheria cell membrane → pathogen (e kang Escherichia coli) ho cheka lera la sele → ho lutla ha thepa ea intracellular → lefu la baktheria, ke hore, ho bolaea libaktheria; Ka nako e ts'oanang, e ka fokotsa endotoxin → ea fokotsa ho ruruha ho bakoang ke LPS.
Thymosin har'a li-peptide tsa immunomodulatory e ka ntlafatsa ts'ebetso ea 'mele ea ho itšireletsa mafung ka ho susumetsa nts'etsopele le kholo ea li-subsets tsa T lymphocyte, ho ntlafatsa bokhoni ba phagocytosis ea macrophages le ho eketsa boemo ba polelo ea interleukin. Namane ea thymosin, joalo ka ha re e bitsa hangata, e sebetsa haholo ho sistimi ea T-lymphocyte ho matlafatsa ts'ebetso ea 'mele ea ho itšireletsa mafung le ho matlafatsa ho hanyetsa mafu.
Il-6 ke karolo ea pleiotropic, e ka laolang kholo le phapang ea lisele tse fapa-fapaneng, ho laola karabelo ea 'mele ea ho itšireletsa mafung, ho arabela ka mokhoa o hlobaetsang le ts'ebetso ea hematopoietic,' me e phetha karolo ea bohlokoa ho thibela tšoaetso ea 'mele ea ho itšireletsa mafung.
LTA e ka ntlafatsa ts'ebetso ea 'mele ea ho itšireletsa mafung ka ho tlama TLR4 / MD2 e rarahaneng → ts'ebetso ea NF-кB tsela ea pontšo → mosebetsi oa phagocytosis oa ↑T lymphocytes le macrophages le mabaka a ho itšireletsa mafung (joaloka TNF-α, IL-6, IL-1β, joalo-joalo).
Boemo ba batho ba fapaneng ba fisioloji ha bo tšoane, bo tla lebisa ho phello ea ho nka peptide ha e tšoane, joalo ka ho ja lijo tse tšoanang batho ba bang ba ja mafura a mangata, batho ba bang ha ba je mafura.
Mabapi le lilemo, hangata phello ea batho ba hōlileng e molemo ho feta bacha; Ho tloha ntlheng ea bophelo bo botle, batho ba kulang ba ja phello ea peptide. Motho ya phelang hantle. Mabapi le mokhathala, batho ba khathetseng ba etsa hantle ho feta ba bang; Batho ba ileng ba etsoa opereishene ba entse hantle ka li-peptide ho feta batho ba sa kang ba buuoa ...
Hobane li-peptide li na le boleng bo phahameng ba phepo e nepahetseng, ho bonolo ho monya, ho fokotsa moroalo oa tšilo ea lijo, ho khothaletsa pholiso ea maqeba le litšoaneleho tse khahlanong le mokhathala, ka hona ho tšoana le moriana o nepahetseng, ha batho ba le maemong a fisioloji, ba hloka li-peptide tse nang le mefuta e fapaneng. mesebetsi ho tlatsana.
Ka tsoelo-pele ea sechaba, batho ba mehleng ea kajeno ba tobane le mathata a mangata a amanang le ho fokotseha ha li-peptide. Ka mohlala, menontsha ea lik'hemik'hale le chefo e bolaeang likokoanyana e tlosa li-enzyme tse senyang liprotheine lijong le ho fokotsa li-enzyme tse tsoang kantle ho naha. Tikoloho ea sejoale-joale ka lebaka la tšilafalo ea moea, tšilafalo ea metsi le mobu, tahlehelo kapa ts'ebetso ea li-enzyme 'meleng oa motho, bokhoni ba' mele oa motho ho theola liprotheine bo ea fokola, tšilo ea lijo le ho senyeha ha li khone ho etsoa ka mokhoa o tloaelehileng, monyetla oa ho fumana li-peptide e fokotsehile, kahoo 'mele oa motho o haelloa ke li-peptide; Mahlaseli a morao-rao a etsa hore ts'ebetso ea 'mele ea motho ea ho itšireletsa mafung e be tlaase, matla a ho cheka le ho senya liprotheine a thibetsoe, mokhoa oa ho monya o sitoa ho monya liprotheine ka mokhoa o tloaelehileng,' me monyetla oa ho fumana li-peptide oa fokotseha.
Khaello ea Peptide e fetohile bothata bo atileng ka lebaka la tšenyo e ngata le tahlehelo ea li-peptide 'meleng oa motho. Ha bokhoni ba 'mele oa motho ba ho kopanya li-peptide bo fokola haholo,' mele oa motho ha o khone ho tlatsa li-peptide ka nako, ka hona hoa hlokahala ho noa lithethefatsi ho fihlela litlhoko tsa 'mele oa motho.
