Tesamorelin peptide (INN) (lebitso la khoebo Egrifta) ke mofuta oa maiketsetso oa hormone ea kholo-hormone-releasing hormone (GHRH) e sebelisoang ho phekola lipodystrophy e amanang le HIV, e amohetsoeng qalong ka 2010. E hlahisoa le ho ntlafatsoa ke Theratechnologies, Inc. ea Canada. Sethethefatsi ke peptide ea maiketsetso e nang le li-amino acid tse 44 tsa GHRH ea motho le tlatsetso ea sehlopha sa trans-3-hexenoic acid.

Tesamorelin peptide ke analogue e tsitsitseng ea peptide ea hypothalamic peptide, Growth Hormone Releasing Hormone (GHRH) e bontšitsoeng bakeng sa ho fokotsa mafura a mpeng a feteletseng ho bakuli ba nang le tšoaetso ea HIV ba nang le lipodystrophy. Lipodystrophy ke boemo ba metabolic bo khetholloang ke ho hanyetsa insulin, kabo ea mafura, le hyperlipidemia e amanang le kalafo ea antiretroviral bakeng sa tšoaetso ea HIV.

Tesamorelin peptide ke analog ea kholo ea hormone (GHRH) e bontšitsoeng ho eketsa hormone ea ho hōla le maemo a IGF-1. Hona joale Tesamorelin ke eona e sebetsang ka ho fetisisa ea GH e lokollang hormone 'marakeng. Ke peptide e nang le ente e hlahisang tlhahiso e kholo ea tlhaho ea HGH (Human Growth Hormone). E tlama le ho susumetsa li-receptor tsa batho tsa GHRH tse nang le matla a tšoanang le a rona a tlhaho a GHRH. Ha e e-s'o bontšoe hore e ama haholo lihomone tse ling tsa pituitary 'meleng.

Gland E Stimulated: Pituitary Gland

MELEMO EA TESAMORELIN:

E eketsa tlhahiso ea tlhaho ea HGH (hormone ea kholo ea motho)

E eketsa IGF-1 (Insulin Growth Factor - 1) ntle le ho fetola litekanyetso tsa tsoekere

Li-triglycerides li fokotsehile

Sehlahisoa se Fokotseng sa Visceral Adipose (VAT)

Carotid Intima Media Size e Fokotsoeng (cIMT)

Kelello e ntlafetseng ho batho ba baholo ba ka holimo ho lilemo tse 60.

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