What is MGF Mechanical Growth Factor?

 KNOWLEDGE    |      2023-03-28

Introduction to MGF:

Mechano Growth Factor Mechano Growth Factor, commonly known simply as MGF, is a splice variant of IGF-1, a growth factor/repair factor derived from exercise or damaged muscle tissue, Makes it harder to identify other IGF variants.

What makes MGF special is its unique role in muscle growth. MGF has the unique ability to induce wasteful tissue growth and improvement by activating muscle stem cells and increasing upregulation of protein synthesis. This unique ability rapidly improves recovery and accelerates muscle growth. In addition to the IGF-1 receptor domain, MGF also initiates muscle satellite (stem cell) cell activation, thereby increasing protein synthesis turnover; Therefore, if used properly, it can greatly improve muscle mass.

IGF-1 is a 70-amino acid hormone with a structure similar to insulin that is secreted by the liver, and IGF-1 secretion is influenced by the secretion and release of growth hormone (GH) in the body. IGF-1 affects almost every cell in the body, mainly because it is involved in cell repair. When muscle tissue is damaged, this creates a reaction in the body called the T

IGF-1 is spliced into two variants, IGF-1Ec and IGF-1Ea, the former being MGF.

MGF splicing variants of two IGFs produced by the liver:

The first is IGF-1EC: this is the first stage to release the igf splicing variant, and it will

Stimulates satellite cell activation

The second is hepatic IGF-IEA: This is a secondary release of igf from the liver, and its anabolic benefits are much smaller than those of the first.

MGF differs from the second variant, IGF-IEa, in that it has a different peptide sequence and is responsible for replenishing satellite cells in skeletal muscle; In other words, it delivers more anabolic benefits and longer effects than the system of the second MGF liver variant.

So you just have to think of MGF as a highly enhanced variant of igf in terms of anabolic benefits. After training, the IGF-I gene splices MGF and then causes hypertrophy and repair of local muscle damage by activating muscle dry cells and other important anabolic processes (including protein synthesis described above) and increasing nitrogen retention in the muscle.

In mice, some studies have shown a 20% increase in muscle mass with a single injection of MGF, but I think many of these studies are inaccurate, but the potential of MGF is undeniable.

The splicing of MGF activates satellite cells, leading to the growth of new muscle fibers in the body. In addition, the presence of MGF increases the body's protein synthesis rate, thus promoting myohypertrophy and enlargement! Get bigger! Get bigger! Of course it is more important to repair the existing 196

Of course, the recovery factors associated with MGF are no doubt the most attractive place for MGF.

While the functionality of MGF may seem a bit confusing at first glance, the process itself becomes fairly simple when you look at it step by step:

1.IGF-1 is released by exercise (occurs after exercise)

2. Splice IGF-1 and MGF

3.MGF activates the recovery of muscle tissue after training damage by activating muscle stem cells

The use of MGF

What happens to your muscles when you train? They break down, cells are damaged, muscle tissue needs to be repaired, and your body produces two forms of MGF splicing variants. The first initial release of the liver 1 variant above facilitates muscle cell recovery. What if MGF was absent? Quite simply, the muscle cells don't repair and die. Muscle cells are mature cells that can't divide, muscle cells are derived from stem cells that divide into muscle cells through mitosis, so the body can't repair tissue through cell replacement after muscle damage, it can only repair the original cells, if the cells are not repaired, they will die. Your muscles will get smaller and weaker. By using MGF, body recovery can be accelerated and muscle tissue cells can be increased by stimulating full maturation of satellite cells. In terms of dose, 200mcg bilateral spot injection is the best choice (spot injection is required for MGF). The only problem with MGF is that its half-life is very short, only 5-7 minutes, and it needs to be used immediately after training to get the best results, while many people don't have time to use it during this window after training.

What is PEG-MGF?

As mentioned above, the biggest drawback of MGF is its short activity time, so a long-acting version of MGF, PEG MGF, has been developed. By adding PEG(polyethylene glycol, a non-toxic additive) to MGF, the half-life of MGF can be increased from minutes to hours. The extended period of activity means that its usefulness and versatility will be greatly improved, and PEG MGF has a systemic effect where the muscle is damaged or diseased, rather than being limited to a single point.

How do I use PEG-MGF

The next area we need to focus on is how to get the most out of MGF's long-acting version. When your muscles are damaged, your body releases pulses of the MGF clip-on variant described above, followed by a long-acting form from the liver with lower anabolic benefits. So it seems like a waste to inject MGF at this point, because you're only weakening the body's own release, not enhancing it. Therefore, using PEG MGF on non-exercise days is actually the best route. Because of muscle damage, MGF has many receptors, and its effects are systemic. By increasing nitrogen retention, protein turnover and satellite cell activation, it will help restore all muscles. By doing so, you're increasing the length of time it takes the body's own muscle repair and growth mechanisms. Using PEG MGF in conjunction with IGF is perfect, but because of the strong receptor affinity of IGF, if you use both IGF-1 and PEG MGF, the effectiveness of MGF will be reduced.

My suggestions are as follows:

IGF DES or IGF1-LR3 is used on training days before training, which does not impair MGF release from the body's liver. IGF-DES was used to rapidly improve the lagged site, and then MGF of 200-400 MCG was used the next day to increase the recovery and growth mechanism. Perfect synergy.

PEG MGF storage

The MGF can be stored in the refrigerator for up to six months. Avoid exposure to heat or sun

Under the light.